Vol2 Paper 10

posted Aug 14, 2018, 12:58 AM by Yaseen Raouf Mohammed   [ updated Sep 4, 2018, 1:20 AM ]
 EFFECTS OF EXCESS VITAMIN B6, B12 INTAKE ON SERUM LIPID PROFILE AND HOMOCYSTEINE AS MARKER FOR CARDIO VASCULAR DISEASE IN RATS


 Ehssan Nissiaf Jasim Al-Obaidy

 Department of Physiology, pharmacology and Biochemistry College of Veterinary Medicine- Diyala University/Iraq

 Muna, M.Ismail

 Department of Physiology, pharmacology and Biochemistry College of Veterinary Medicine- Diyala University/Iraq

 Nadia Ahmed Salih Al-Guburi

 Department of Chemistry College of Education –Tikrit University /Iraq

 ABSTRACT
Vitamin B12, B6 being water-soluble is excreted in the urine when administered in excess. Lipid profile and Homocystien is important relation with heart disease. High levels of the amino acid homocysteine in the blood are associated with heart disease increased intake of vitamin B12 has been found to decrease homocysteine levels, Aim: The present study was undertaken to investigate the effects of dietary excess of vitamin B6 and B12 total lipid and the Homocystein. Materials and Methods: A total of 48 rabbits were included in the study. Control groups (CG-10, n = 8 for 10 days; CG-15, n = 8 for 15 days; CG-20, n = 8 for 20 days). The experimental groups (EG-10, n = 8; EG-15, n = 8; EG-20, n = 8) received 5 mg/ kg vitamin B6, B12 daily for 10 days, 15 days and 20 days .HDL,Cholesterol and total lipid levels and Homocystiene were measured and compared in CGs and EGs. Results: The total serum cholesterol levels were significantly lower (P < 0.05) although serum HDL levels were significantly higher (P < 0.01) in all EGs. Total serum lipid levels were higher in EG-15 and EG-20 groups than in CGs. a relationship between serum total lipid and HDL levels in theEG-15 and EG-20 groups is suggested. Conclusions: Dietary excess of vitamin B6, B12 intake reduces serum total cholesterol levels, but not serum HDL and total lipid levels, and also causes decrease in homocystine levels as treatment.


 Keywords: 
Vitamin B12, B6, Cholesterol, Lipid profile, Homocystiene.



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