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Vol2 Paper 16

posted Aug 24, 2018, 6:52 AM by Yaseen Raouf Mohammed   [ updated Sep 4, 2018, 2:04 AM ]
 MODIFIED SYNTHESIS OF MOCLOBEMIDE-ANTIDEPRESSANT DRUG.


 Hezha O. Rasul

 Chemistry Department, College of Science, University of Sulaimani, Sulaimani, Iraq.

 Diary I. Tofiq

 Chemistry Department, College of Science, University of Sulaimani, Sulaimani, Iraq.

 ABSTRACT
The target synthesized molecule in this study was moclobemide, which is a reversible inhibitor of monoamine oxidase drug used as an antidepressant. The amide, moclobemide was generated from two starting materials (acyl chloride and an amine) by an acylation reaction. The acyl chloride was 4-chlorobenzoyl chloride and the amine was 4-(2-aminoethyl)
morpholine, a good yield of the hydrochloride salt of moclobemide has formed in the first step. Then, the salt was purified by recrystallization process from aqueous ethanol. Finally, the purified salt was neutralized with aqueous ammonia, in addition to extracting and isolating the free-base form of moclobemide. The main reason of this study was to modify
a synthetic route of moclobemide drug with the purpose of increasing the yield of the final product comparing to the earlier studies. In accordance with previous studies, the yield of the product was reasonably good and higher by % 32.72; this result was higher than the previously reported studies. Then IR spectrum and 1H NMR spectroscopy analyses have been
recorded to confirm the presence of the amide functionality and the chemical structure of the synthesized compound. Mechanisms of Moclobemide hydrochloride salt and product formation were suggested.


 Keywords:
Antidepressant; Moclobemide; Drug; Recrystallization; Schiff base.



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