ICNS 2017‎ > ‎Research Papers‎ > ‎

Vol2 Paper 9

posted Aug 14, 2018, 12:51 AM by Yaseen Raouf Mohammed   [ updated Sep 4, 2018, 1:18 AM ]

 Dereen Najat

 University of Sulaimani/college of Science/chemistry department.

Vitamin D deficiency may cause serious health complications in both pregnant women and their fetuses. Despite the abundance of sunlight in the Middle East, many research groups confirmed alarming vitamin D deficiency in the region. For the first time, this study investigated the association between vitamin D levels with miscarriage incidences in pregnant women residing in Sulaimani city. The participants in this study were 390 vieled and nonviled pregnant women. Each participant completed a questionnaire about her lifestyle, including smoking status and nutritional supplement usage. An electrochemiluminescence binding assay was used to measure non-fasting serum concentration of total 25-hydroxyvitamin D. SPSS software was used for statistical analysis, P< 0.05 was considered significant throughout all the tests. Of all the women in this study, 82.3% were severely vitamin D deficient, 9.7 % were vitamin D insufficient, whereas only 7.9 % of the pregnant women were vitamin D sufficient. In total 17.1% of the study participants had pregnancy loss (miscarriage, still birth) and 8.9% of the participants had miscarriages. In conclusion, a high percentage of participitants had vitamin D deficiency; also vitamin D deficiency was not associated with pregnancy losses; further research is needed to confirm vitamin D roles in pregnancy losses. 

25 hydroxyvitamin D; miscarriages; dietary calcium intake; dietary vitamin D intake; vitamin D deficiency; prevalence.

[1] Gorham, E.D. et al., 2007. Optimal Vitamin D Status for Colorectal Cancer Prevention. American Journal of Preventive Medicine, 32[3], pp.210–216.
[2] Botella-Carretero, J.I. et al., 2007. Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity. Clinical nutrition [Edinburgh, Scotland], 26[5], pp.573–80.
[3] Dobnig, H. et al., 2008. Independent Association of Low Serum 25-Hydroxyvitamin D and 1, 25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality. Archives of Internal Medicine, 168[12], p.1340.
[4] Zittermann, A. et al, 2003. Vitamin D in preventive medicine: are we ignoring the evidence? British Journal of Nutrition
[5] Spedding, S., 2014. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients, 6[4], pp.1501–18
[6] Vandevijvere, S. et al., 2012. High prevalence of vitamin D deficiency in pregnant women: a national cross-sectional survey. PloS one, 7[8], p.e43868.
[7] Hovsepian, S. et al., 2011. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. Journal of health, population, and nutrition, 29[2], pp.149–55.
[8] Nichols, E.K. et al., 2012. Vitamin D status and determinants of deficiency among non-pregnant Jordanian women of reproductive age. European journal of clinical nutrition, 66[6], pp.751–6
[9] Al-Turki, H.A. et al., 2008. 25-Hydoxyvitamin D levels among healthy Saudi Arabian women.
Saudi medical journal, 29[12], pp.1765–8.
[10] Karras, S.N. et al., 2015. Vitamin D during pregnancy: why bservational studies suggest deficiency and interventional studies show no improvement in clinical outcomes? A narrative
review. Journal of Endocrinological Investigation, 38[12], pp.1265–1275.
[11] Pérez-López, F.R. et al., 2015. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled
trials. Fertility and Sterility, 103[5], p.1278–1288.e4.
[12] Al-Shaikh, G.K. et al., 2016. Impact of vitamin D deficiency on maternal and birth outcomes in the Saudi population: a cross-sectional study. BMC pregnancy and childbirth, 16, p.119.
[13] Everett, C. et al., 1997. Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice. BMJ, 315[7099].
[14] Lathi, R. et al., 2011. First Trimester Miscarriage Evaluation. Seminars in Reproductive Medicine, 29[6], pp.463–469.
[15] Itoh, H. et al., 2011. Association between night-shift work and serum 25-hydroxyvitamin D levels in Japanese male indoor workers: a cross-sectional study. Industrial health, 49[5], pp.658–62
[16] Leridon, H. et al., 1976. Facts and artifacts in the study of intra-uterine mortality: A reconsideration from pregnancy histories. Population Studies, 30[2], pp.319–335.92
[17] Poorolajal, J. et al., 2014. Predictors of miscarriage: a matched case-control study. Epidemiology and health, 36, p.e2014031.
[18] Brannon, P.M. & Picciano, M.F. et al., 2011. Vitamin D in Pregnancy and Lactation in Humans. Annual Review of Nutrition, 31[1], pp.89–115.
[19] Hussain, A.N. et al., 2014. Increasing trends and significance of hypovitaminosis D: a population- based study in the Kingdom of Saudi Arabia. Archives of Osteoporosis, 9[1], p.190.
[20] Everett, C. et al., 1997. Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice. BMJ, 315[7099].
[21] Liu, N.Q. & Hewison, M., 2012. Vitamin D, the placenta and pregnancy. Archives of Biochemistry and Biophysics, 523[1], pp.37–47.
[22] Ma, R. et al., 2012. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. American journal of physiology. Endocrinology and metabolism, 303[7], pp.E928-35.[23] Pandey, S. & Tyagi, R., 2014. Risk factors for miscarriage from a prevention perspective: a nationwide follow-up study. BJOG: An International Journal of Obstetrics & Gynaecology,121[11], pp.1439–1439.

View All Artical